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The Shraga Segal Department of Microbiology, Immunology and Genetics:
Blocking IL-1
β
reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN.
Proc Natl Acad Sci U S A
. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. Epub 2018 Dec 13.
The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.
Feldman M, Vershinin Z, Goliand I, Elia N, Levy D.
Proc Natl Acad Sci U S A
. 2019 Jan 22;116(4):1235-1240. doi: 10.1073/pnas.1804407116. Epub 2019 Jan 8.
Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy.
Ghosh S, Prasad M, Kundu K, Cohen L, Yegodayev KM, Zorea J, Joshua BZ, Lasry B, Dimitstein O, Bahat-Dinur A, Mizrachi A, Lazar V, Elkabets M, Porgador A.
Front Oncol. 2019 Jan 22;9:17. doi: 10.3389/fonc.2019.00017. eCollection 2019.
High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo.
Marciano R, Prasad M, Ievy T, Tzadok S, Leprivier G, Elkabets M, Rotblat B.
Cancers (Basel). 2019 Jan 30;11(2). pii: E156. doi: 10.3390/cancers11020156.
MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer.
Novoplansky O, Fury M, Prasad M, Yegodayev K, Zorea J, Cohen L, Pelossof R, Cohen L, Katabi N, Cecchi F, Joshua BZ, Popovtzer A, Baselga J, Scaltriti M, Elkabets M.
Int J Cancer. 2019 Jan 29. doi: 10.1002/ijc.32170. [Epub ahead of print]
Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?
Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Iacubuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM.
Clin Cancer Res. 2019 Jan 7. doi: 10.1158/1078-0432.CCR-18-3042. [Epub ahead of print]
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Pediatrics and Infectious Diseases
Hazan G, Dagan R, Friger M. Maternal education is inversely related to vaccination delay among infants and toddlers. Journal of Pediatrics 2019;205:120-125.e.2
Weinberger DM, Pitzer VE, Regev-Yochay G, Givon-Lavi N, Dagan R. Association between the decline in pneumococcal disease in unimmunized adults and vaccine-derived protection against colonization in toddlers and preschool-aged children. American Journal of Epidemiology 2019;188:160-168.
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Department of Physiology and Cell Biology
Genes Brain Behav. 2019 Jan;18(1):e12547. doi: 10.1111/gbb.12547.
Sadigurschi N, Golan HM
Maternal and offspring methylenetetrahydrofolate-reductase genotypes interact in
a mouse model to induce autism spectrum disorder-like behavior.
Genes Brain Behav. 2019 Jan;18(1):e12547. doi: 10.1111/gbb.12547.
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